Designer diet for prostate cancer

Designer studies for health promotion

"Other fruits and vegetables have been shown to also reduce the risk of prostate cancer and are likely to act through other mechanisms," says Professor Mithen.

"Once we understand these, we can provide much better dietary advice in which specific combinations of fruit and vegetable are likely to be particularly beneficial. Until then, eating two or three portions of cruciferous vegetable per week, and maybe a few more if you lack the GSTM1 gene, should be encouraged."

Notes for editors:

Funding: The work was supported by the Biotechnology and Biological Sciences Research Council (BBSRC).

Cruciferous vegetables include broccoli, Brussels sprouts, cauliflower, cabbage, rocket, watercress, garden cress, kale, bok choy, radish, horseradish and wasabi.

The broccoli used in this study is a high glucosinolate variety. The variety was developed at the John Innes Centre in Norwich, and then licensed to Seminis Inc for commercialisation by Plant Bioscience Ltd.

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Citation: Traka M, Gasper AV, Melchini A, Bacon JR, Needs PW, et al. (2008) Broccoli Consumption Interacts with GSTM1 to Perturb Oncogenic Signalling Pathways in the Prostate. PLoS ONE 3(7): e2568. doi:10.1371/journal.pone.0002568

PLEASE ADD THE LINK TO THE PUBLISHED ARTICLE IN ONLINE VERSIONS OF YOUR REPORT (URL live from July 2): http://www.plosone.org/doi/pone.0002568.

PRESS-ONLY PREVIEW: http://www.plos.org/press/pone-03-07-mithen.pdf