Researchers identify genetic variation to predict initial response to warfarin

Resources:

• Pharmacogenetics Research Network, www.nigms.nih.gov/initiatives/PGRN/

• Pharmacogenetics and Pharmacogenomics Knowledge Base (PharmGKB), an integrated knowledge base for pharmacogenetics linking phenotypes and genotypes, supported by the NIH/NIGMS Pharmacogenetics Research Network and Database: http://www.pharmgkb.org/.

• "FDA Approves Updated Warfarin (Coumadin) Prescribing Information -- New Genetic Information May Help Providers Improve Initial Dosing Estimates of the Anticoagulant for Individual Patients," News release, Food and Drug Administration, August 16, 2007. http://www.fda.gov/bbs/topics/NEWS/2007/NEW01684.html

• "Genetic Variation Alters Response to Common Anti-Clotting Drug," News release, National Institute of General Medical Sciences, June 2, 2005. http://www.nigms.nih.gov/news/results/060205.html.

• WarfarinDosing.org, a free Web tool for health care professionals to estimate the beginning dose for patients who are starting warfarin therapy. Supported in part by NHLBI and the Barnes-Jewish Hospital Foundation.

Part of the National Institutes of Health (NIH), the National Heart, Lung, and Blood Institute (NHLBI) plans, conducts, and supports research related to the causes, prevention, diagnosis, and treatment of heart, blood vessel, lung, and blood diseases; and sleep disorders. The Institute also administers national health education campaigns on women and heart disease, healthy weight for children, and other topics. NHLBI press releases and other materials are available online at www.nhlbi.nih.gov.

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