Researcher: 'Optical biopsy' for breast cancer increasingly accurate

GAINESVILLE, Fla. — Most biopsies following mammograms reveal benign abnormalities, not cancer.

But women may not have to endure the medical costs, stress and potential complications that accompany such invasive biopsies forever. A University of Florida biomedical engineering researcher is making progress on an "optical biopsy" that has the potential to determine whether growths are cancerous without ever puncturing the skin.

"At this stage, it is just too early for optical tomography to be a screening tool," said Huabei Jiang, the J. Crayton Pruitt Family professor of biomedical engineering, who has spent more than a decade developing the technique at UF and Clemson University. "But you can pretty much say that it is highly likely it can become a diagnostic tool, an adjunct to X-ray mammography."

Surgical biopsies have long been the gold standard for determining whether growths are cancerous. But at least three out of four biopsies following mammograms conclude that observed abnormalities are benign and that no intervention was needed, Jiang said. Depending on if the biopsies are performed with needles or surgery, that can mean added cost, recuperation and potential scarring or other complications — all ultimately unnecessary.

Jiang has devoted much of his career to an alternative: "phase-contrast diffuse optical tomography," a screening technology that roots out breast cancer not with cutting tools and laboratory tests but with light and computing power.

He recently completed the third generation of his apparatus — a bed with an array of fiber optic laser lights and detectors mounted within a hole where the patient places her breast.

Light from the harmless lasers enters the breast and scatters. Most gets absorbed in the tissue, but some reaches the detectors. With enough light hitting the detectors from enough different directions, there is sufficient data for Jiang's computer algorithms to create an image of the breast's interior. This image suggests either benign conditions or some of the telltale signs of cancer that are completely invisible to standard X-ray mammograms — for example, a high density of blood vessels snaking around a likely tumor.