Men at increased risk of death from pneumonia compared to women

Men come to emergency departments sicker, more likely to die over the next year, University of Pittsburgh School of Medicine study finds

TORONTO, May 18 – Men who come to the hospital with pneumonia generally are sicker than women and have a higher risk of dying over the next year, despite aggressive medical care, according to a study being presented Tuesday, May 20, at the 104th International Conference of the American Thoracic Society. Scientific sessions are scheduled May 16 to 21 in Toronto.

“It is well known that women live longer than men. We have always assumed that these differences occur because men engage in riskier behaviors and have a greater burden of chronic diseases,” said Sachin Yende, M.D., study co-author and assistant professor in the Department of Critical Care Medicine, University of Pittsburgh School of Medicine. “Our study showed that men were more likely to die up to a year after pneumonia, despite adjusting for health behaviors and chronic conditions. Further, our findings indicate this may be linked to differences in immune response.”

The University of Pittsburgh researchers evaluated data from 1,136 men and 1,047 women with symptoms of pneumonia who were treated at 28 hospital emergency departments in the United States.

On average, men arrived at the emergency departments with poorer vital signs, were more likely to be smokers and had a greater variety of complicating health conditions. After hospitalization, men received timely antibiotic treatments more often than women and were twice as likely to be admitted immediately to intensive-care units.

“The gender disparity on aggressiveness of hospital care is appropriate, given that men tended to be significantly sicker than women,” said Michael Reade, D.Phil., first author, former fellow in Pitt’s Department of Critical Care Medicine, and assistant professor at the University of Melbourne, Australia. Investigators adjusted results for age, race, tobacco use, other demographic characteristics, chronic health conditions, health behaviors and levels of treatment. “Even so, men had a 30 percent higher risk of death, and the social factors we examined were not sufficient to explain the differences we observed.”