JCI table of contents: March 20, 2008

TITLE: A CD28 superagonistic antibody elicits 2 functionally distinct waves of T cell activation in rats

AUTHOR CONTACT:
Holger M. Reichardt
University of Goettingen Medical School, Goettingen, Germany.
Phone: 49-551-393365; Fax: 49-551-395843; E-mail: .

View the PDF of this article at: https://www.the-jci.org/article.php?id=32698

ACCOMPANYING COMMENTARY

TITLE: The calm after the cytokine storm: lessons from the TGN1412 trial

AUTHOR CONTACT:
E. William St. Clair
Duke University Medical Center, Durham, North Carolina, USA.
Phone: (919) 684-4499; Fax: (919) 684-8358; E-mail: .

View the PDF of this article at: https://www.the-jci.org/article.php?id=35382

ONCOLOGY: The protein TM4SF5 lets tumor cells grow out of control

A characteristic of tumor cells is that they grow in an uncontrolled manner. One reason for this is that although normal cells stop growing when they contact one another (a process known as contact inhibition), tumor cells do not. New data, generated by Jung Weon Lee and colleagues, at Seoul National University, Republic of Korea, has now indicated that the protein TM4SF5 has a crucial role in the ability of human hepatocarcinoma cells to overcome contact inhibition and grow in an uncontrolled manner.

In the study, TM4SF5 was found to be overexpressed in human hepatocarcinoma tissue. This overexpression mediated cellular effects that caused the tumor cells to undergo a process known as epithelial-mesenchymal transition, and resulted in uncontrolled growth, both in vitro and when the cells were injected into mice. The importance of these data, which imply TM4SF5 has a crucial role in cancer progression, is discussed in an accompanying commentary by Ruth Muschel and Annamaria Gal from the University of Oxford, United Kingdom.

TITLE: Tetraspanin TM4SF5 mediates loss of contact inhibition through epithelial-mesenchymal transition in human hepatocarcinoma

AUTHOR CONTACT:
Jung Weon Lee
Seoul National University, Seoul, Republic of Korea.
Phone: 82-2-3668-7030; Fax: 82-2-766-4487; E-mail: .

View the PDF of this article at: https://www.the-jci.org/article.php?id=33768

ACCOMPANYING COMMENTARY

TITLE: Tetraspanin in oncogenic epithelial-mesenchymal transition

AUTHOR CONTACT:
Ruth J. Muschel
University of Oxford, Oxford, United Kingdom.
Phone: 44-0-1865-857-427; Fax: 44-0-1865-857-533; Email: .

View the PDF of this article at: https://www.the-jci.org/article.php?id=35308