JCI table of contents: January 2, 2007

TITLE: Myd88-dependent positioning of Ptgs2-expressing stromal cells maintains colonic epithelial proliferation during injury

AUTHOR CONTACT:

Thaddeus S. Stappenbeck
Washington University School of Medicine, St. Louis, Missouri, USA.
Phone: (314)-362-4214; Fax: (314)-362-7487; E-mail: .

Jim Dryden
Associate Director, Broadcast Services
Medical Public Affairs, Washington University, St. Louis, Missouri, USA
Phone: (314)-286-0110; Fax: (314)-286-0199; e-mail .
View the PDF of this article at: https://www.the-jci.org/article.php?id=29159

ACCOMPANYING COMMENTARY

TITLE: Prostaglandin-secreting cells: a portable first aid kit for tissue repair

AUTHOR CONTACT:

Ruslan Medzhitov
Yale University School of Medicine, New Haven, Connecticut, USA.
Phone: (203) 785-7541; Fax: (203) 785-4461; E-mail: .
View the PDF of this article at: https://www.the-jci.org/article.php?id=30865

METABOLIC DISEASE

How to trap heart attack–inducing lipoproteins in the blood

Atherosclerosis is a disease of the blood vessels that causes many problems, including heart attacks. It is caused by a buildup of fat (lipid)-containing macrophages (the rubbish-collecting cells of the immune system) in the arteries. The presence in the blood of high levels of remnant lipoproteins, cholesterol-rich particles that are produced as the large lipoprotein complexes that transport lipids around the body are degraded, potently promotes the development of atherosclerosis. Therefore, understanding the mechanisms by which lipoprotein remnants are removed from the circulation is an area of intensive research and two studies appearing in the January issue of the Journal of Clinical Investigation provide new insights into these mechanisms.