Is hybridoma production about to take a quantum leap forward?

The researchers then tested the proliferation rate of primary human fibroblast cells incubated either in NPD-based or DI-based media. Unlike the CHO cells, these are sensitive to cell density and were grown at two different starting dilutions. Here the NPD-based media had the opposite effect: the CHO cells displayed a slower proliferation rate than that of DI-based media (in both dilutions). The researchers concluded: “As is evident from the curves, primary human fibroblasts proliferated poorly in NPD-based media, compared to DI-based media.... they appear to sense the lower effective cell density.”

The above paper demonstrates the remarkable power of Neowater® for enhancing the stabilization, activity and proliferation of cells and antibodies - as well as inhibiting the proliferation of other cells. This is just one example of the wide research potential that Neowater® offers, which will eventually impact the healthcare industry. Imagine the novel and cutting-edge methodologies suddenly available to stem-cell therapeutics, site-specific antibody treatments, and targeted anti-cancer drugs using fully human mAbs.

Many promising biomed and therapeutic concepts that have been shelved, blocked by the basic difference between regular water and intracellular water, can now cross the "molecular water barrier", thanks to the nanoparticle restructuring capability of Neowater®. We can expect a new era in R&D as these concepts are facilitated by Neowater® technology and find realization in therapeutic applications.

* “ENHANCEMENT OF HYBRIDOMA FORMATION, CLONEABILITY AND CELL PROLIFERATION IN A NANOPARTICLE-DOPED AQUEOUS ENVIRONMENT”, authored by Natalie Gavrilov-Yusim1, Ekaterina Hahiashvili1, Marina Tashker1, Victoria Yavelsky1, Ohad Karnieli2 and Leslie Lobel1

1Department of Virology and Developmental Genetics, Ben Gurion University of the Negev, Beer-sheva 84105, Israel
2Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel)