First analysis of platypus genome may impact disease prevention

Mark Batzer decodes 'jumping genes' to trace the evolution of mammals

BATON ROUGE – There’s no doubt about it ... the platypus is one odd duck-billed, egg-laying, lactating mammal. With adaptations like webbed feet to fit its aquatic lifestyle and the poison spurs that decorate males, the platypus represents for many a patchwork of evolutionary development. But LSU’s Mark Batzer, along with an international consortium of scientists led by Wes Warren at Washington University in Saint Louis, Mo., has taken this theory to an entirely new level, proving that platypus looks aren’t only skin-deep – their DNA is an equally cobbled-together array of bird, reptile and mammalian lineages.

The consortium conducted the first analysis of platypus DNA in what was the largest platypus population genetics study to date.

“Their genomic organization was strange and a little unexpected,” said Batzer, Andrew C. Pereboom Alumni Departmental Professor of Biological Sciences at LSU and one of the principle investigators of the project. “It appeared much more bird- and reptile-like than mammalian, even though it is indeed classified as a mammal. It’s an ancient animal, too, and it has remained relatively primitive and unchanged, both in physical appearance and genetically.”

What does this discovery mean for the public? The very real potential for advances in human disease prevention and a better understanding of mammalian evolution.

“This is a huge genetic step,” said Batzer. “Understanding is key. We’re learning a lot about mammalian gene regulation and immune systems, which has huge implications for disease susceptibility research. We hope to, in time, identify the underlying causes and methods of disease prevention in humans.”

The platypus was chosen as the subject of this study in large part due to its strange appearance, but other selection factors include the species’ endangered status in its only indigenous habitat, Australia. Platypuses are extremely shy by nature and there has been little success in breeding the animals while in captivity. Researchers hope that some of the clues unearthed in platypus DNA might lead to new directions in conservation efforts.