American Chemical Society’s Weekly PressPac -- May 7, 2008

ARTICLE #2 FOR IMMEDIATE RELEASE

“Super yeasts” produce 300 times more protein than previously possible
Journal of the American Chemical Society

Researchers in California report development of a new kind of genetically modified yeast cell that produces complex proteins up to 300 times more than possible in the past. These “super yeasts” could help boost production and lower prices for a new generation of protein-based drugs that show promise for fighting diabetes, obesity, and other diseases, the researchers suggest. Their study is scheduled for the May 14 issue of the Journal of the American Chemical Society, a weekly publication.

In their report, Lei Wang and Qian Wang explain that the yeasts are intended for speeding production of proteins containing so-called “unnatural amino acids” (UAAs). Living things normally use the same basic set of 20 amino acids to make proteins. Scientists have made additional amino acids, the UAAs, which show promise for building new proteins with a broad range of medical and industrial applications. However, researchers had had difficulty in efficiently incorporating these UAAs into useful protein products.

Wang and Wang are reporting a solution to that problem. They inserted parts of the simple but highly efficient protein-making machinery of E. coli bacteria into the advanced but inefficient protein-making machinery of yeast cells. The result was a best-of-both world’s creation: A genetically-engineered yeast cell that produces complex proteins containing UAAs at levels 300 times higher than normal yeast cells. — MTS

ARTICLE #2 FOR IMMEDIATE RELEASE “New Methods Enabling Efficient Incorporation of Unnatural Amino Acids in Yeast”

DOWNLOAD FULL TEXT ARTICLE http://dx.doi.org/10.1021/ja800894n

CONTACT:
Lei Wang, Ph.D.
The Salk Institute for Biological Studies
La Jolla, California 92037
Phone: 858-453-4100, ext. 1974
Fax: 858-597-0855
Email:

Scientists have developed a microwave heating system for ballast water treatment that could help rid waterways of invasive species, such as the zebra mussel (above), that annually cause billions of... Click here for more information.

ARTICLE #3 FOR IMMEDIATE RELEASE